Cardiac myosin binding protein-C (cMyBP-C) is a fundamental component of the cardiac sarcomere involved in regulating systolic and diastolic activity, processes which must be tightly maintained to preserve cardiac function. Importantly, as a non-enzymatic protein, cMyBP-C relies solely on post-translational modifications and protein-protein interactions in order to modulate its function, and does so through phosphorylation, glutathionylation and acetylation amongst others. Although some are better understood than others, these modifications may represent novel therapeutic routes to modulate cMyBP-C function in the treatment of cardiac disease.

中文翻译：

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心肌肌球蛋白结合蛋白-C 的翻译后调节：图形回顾

心脏肌球蛋白结合蛋白-C (cMyBP-C) 是心脏肌节的基本成分，参与调节收缩和舒张活动，必须严格维持这些过程以保护心脏功能。重要的是，作为一种非酶促蛋白，cMyBP-C 仅依靠翻译后修饰和蛋白质-蛋白质相互作用来调节其功能，并通过磷酸化、谷胱甘肽化和乙酰化等方式来实现。尽管有些比其他更容易理解，但这些修改可能代表了在心脏病治疗中调节 cMyBP-C 功能的新治疗途径。