The development of new diabetes treatment strategies has garnered much interest given that conventional management therapies for type 1 diabetes fail to provide optimal glycemic control while creating a high burden of self-care to patients. Stimuli-responsive, “closed-loop” systems are particularly attractive due to their ability to mimic dynamic ß cell function by releasing insulin in response to fluctuating glucose levels in real-time and with minimal patient discomfort. In this short review, we focus on stimuli-responsive, reservoir-based insulin delivery devices. We explore and evaluate systems that are either physiologically or externally triggered. While obstacles remain before such technologies can be translated to clinical settings, further optimization of delivery systems forebodes that these technologies will have a tremendous impact on type 1 diabetes treatment.

鉴于针对1型糖尿病的常规管理疗法无法提供最佳的血糖控制，同时又给患者带来了很大的自我护理负担，因此新的糖尿病治疗策略的发展引起了人们的极大兴趣。刺激响应的“闭环”系统特别吸引人，因为它们能够通过响应实时变化的葡萄糖水平释放胰岛素来模拟动态ß细胞功能，并使患者的不适感降至最低。在这篇简短的评论中，我们重点介绍刺激性，基于储库的胰岛素输送设备。我们探索和评估生理或外部触发的系统。尽管在将此类技术转化为临床环境之前仍然存在障碍，