Abstract

Magnetite-gold hybrid magnetic nanoparticles of the dumbbell type were used to immobilize two proteins: α-chymotrypsin and the Bowman–Birk inhibitor. It is shown that under the influence of a low-frequency magnetic field (50 Hz), the activity of chymotrypsin bound in a complex with an inhibitor is drastically reduced depending on the magnetic field induction. We hypothesize that this effect is related to the aggregation of magnetic nanoparticles under the influence of a magnetic field.

中文翻译：

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使用非加热低频磁场固定在磁铁矿-金杂化纳米粒子上的α-胰凝乳蛋白酶-鲍曼-伯克抑制剂对的生物催化调控。

摘要

哑铃型磁铁矿-金杂化磁性纳米颗粒用于固定两种蛋白质：α-胰凝乳蛋白酶和Bowman-Birk抑制剂。结果表明，在低频磁场（50 Hz）的影响下，与抑制剂结合的胰凝乳蛋白酶的活性会根据磁场的感应而大大降低。我们假设这种效应与磁场作用下磁性纳米粒子的聚集有关。