Abstract

Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that an increase of up to 35% of the protein release rate occurred when the MALip are exposed to the LF AMF (frequency 110 Hz, intensity 75–150 kA/m) for 5–15 min. The research provides prospects for the development of remotely controlled protein release from liposomes.

中文翻译：

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低频非加热磁场下用于远程控制高分子药物释放的磁性脂质体

摘要

开发了与磁铁矿磁性纳米颗粒（MNP）共轭的磁性阴离子脂质体（MALip），用于在暴露于低频非加热磁场（LF AMF）的情况下控制蛋白酶抑制剂（BBI）的释放。结果表明，当MALip暴露于LF AMF（频率110 Hz，强度75-150 kA / m）达5-15分钟时，蛋白质释放速率最多可提高35％。该研究为从脂质体释放遥控蛋白质的发展提供了前景。