Numerous classifications are used to discern metabolically healthy obese (MHO) from metabolically abnormal obese (MAO) individuals. The goal of this study was to compare a single phenotype approach, adiposopathy (i.e., the plasma adiponectin/leptin ratio), with four commonly used classifications (International Diabetes Federation (IDF), Karelis, Lynch, Wildman), all based on obesity with other risk factors), for their ability to discern phenotypic differences between MAO and MHO postmenopausal women. Anthropometry, body composition, blood pressure, cardiorespiratory fitness (CRF), lipid-lipoprotein, hepatic, inflammatory, and adipokine profiles, as well as glucose-insulin homeostasis, were assessed in 79 obese sedentary postmenopausal women (60 ± 5 years; body mass index, BMI, 34.0 ± 3.7 kg/m²). Abdominal subcutaneous adipose tissue (SCAT) expression of selected genes involved in fatty acid metabolism and inflammation was used as markers of tissue state (n = 48). Beyond their intrinsic criteria, adiposopathy was almost as effective as the Karelis definition in discerning differences in MHO for adiposity (reduced body weight, BMI, waist circumference, and fat mass), lipid-lipoprotein (lower triacylglycerol and higher HDL-cholesterol levels, reduced atherogenic ratios) and adipokine (higher adiponectin and lower leptin levels) profiles, and glucose-insulin homeostasis (lower insulin resistance) as well as for some SCAT gene expression related to lipolysis and lipogenesis, but was the only one able to distinguish these subjects for greater CRF. The other classifications revealed fewer differences between MAO and MHO women. These data suggest that considering a marker of AT dysfunction such as adiposopathy either alone or in addition to other criteria could be potentially interesting in discerning the MHO phenotype.

大量分类用于区分代谢异常的肥胖（MAO）个体的代谢健康的肥胖（MHO）。这项研究的目的是比较单一表型方法，脂肪病（即血浆脂联素/瘦素比例）与四种常用分类（国际糖尿病联盟（IDF），Karelis，Lynch，Wildman），均基于肥胖与其他危险因素），因为他们有能力辨别MAO和MHO绝经后妇女之间的表型差异。在79位肥胖的绝经后绝经后妇女（60±5岁；体重）中评估了人体测量学，身体组成，血压，心肺健康（CRF），脂质脂蛋白，肝，炎性和脂肪因子的分布以及葡萄糖-胰岛素的体内稳态。指数，BMI，34.0±3.7 kg / m ²）。腹部皮下脂肪组织（SCAT）表达的参与脂肪酸代谢和炎症的特定基因被用作组织状态的标志物（n = 48）。除了其固有标准外，脂肪病在识别肥胖的MHO（体重减轻，BMI，腰围和脂肪量），脂-脂蛋白（较低的三酰甘油和较高的HDL-胆固醇）差异方面几乎与Karelis定义一样有效。动脉粥样硬化发生率）和脂肪因子（脂联素水平较高和瘦素水平较低）概况，葡萄糖-胰岛素稳态（胰岛素抵抗性较低）以及与脂解和脂肪生成有关的某些SCAT基因表达，但它是唯一能够区分这些受试者的更大的CRF。其他分类表明，MAO和MHO妇女之间的差异较小。