Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2020-09-24 , DOI: 10.1007/s11418-020-01450-5 Sujitra Hanthanong 1 , Siwattra Choodej 2 , Thammarat Aree 2 , Khanitha Pudhom 2
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Abstract
A new rearranged clerodane-type diterpene (1), tinobaenzigeride, and a new rearranged clerodane glucoside (2) were isolated from the stems of Tinospora baenzigeri, along with four known compounds (3‒6). Their structures were elucidated by spectroscopic data analysis. In addition, the structure and configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 are a rare example of rearranged clerodanes, since it contains a fully oxygenated tetrahydrofuran moiety. The isolated compounds were evaluated for their cytotoxicity against Hep-G2 and MCF-7 cancer cells, none of them did show any significant activity at 25 μM.
Graphic abstract
中文翻译：
来自泰国Tinospora baenzigeri的两个新的重排的双环戊烷二萜。
摘要
一种新的重排的克罗类双萜（1），tinobaenzigeride，和一个新的重排的克罗葡糖苷（2）中分离从茎的青牛baenzigeri，具有四个已知化合物（沿3 - 6）。通过光谱数据分析阐明了它们的结构。另外，通过单晶X射线衍射分析确认了1的结构和构型。化合物1是重排的claododanes的罕见例子，因为它含有完全氧化的四氢呋喃部分。评估分离出的化合物对Hep-G2和MCF-7癌细胞的细胞毒性，它们在25μM时均未显示任何显着活性。
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