Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2020-09-24 , DOI: 10.1007/s11418-020-01449-y Hiromi Niwa 1 , Shin-Ichiro Kurimoto 2 , Takaaki Kubota 2 , Mitsuhiro Sekiguchi 1
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Abstract
The production and accumulation of advanced glycation end products (AGEs) have been implicated in diabetes and diabetic complication. This study was conducted as a search for an AGE inhibitor from brown alga, Sargassum macrocarpum. Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC50: 1.0 mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control).
Graphic abstract
中文翻译：
Macrocarquinoids AC，来自马尾藻的新类萜。
抽象的
晚期糖基化终产物（AGE）的产生和积累与糖尿病和糖尿病并发症有关。本研究旨在从褐藻马尾藻中寻找 AGE 抑制剂。以AGEs抑制活性为指标进行分离纯化，分离得到11个类萜，其中3个为新化合物：大类胡萝卜素A( 1 )、B( 6 )、C( 9 )。使用 NMR 光谱分析和 2D 技术阐明了它们的结构。所有测试的化合物均表现出 AGE 抑制活性。特别是，大类胡萝卜素C ( 9 ) 具有分离化合物中最强的活性(IC 50 ：1.0 mM)。该活性强于氨基胍（阳性对照）。
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