Prophylactic and therapeutic vaccines for the alphaherpesviruses including varicella zoster virus (VZV) and herpes simplex virus types 1 and 2 have been the focus of enormous preclinical and clinical research. A live viral vaccine for prevention of chickenpox and a subunit therapeutic vaccine to prevent zoster are highly successful. In contrast, progress towards the development of effective prophylactic or therapeutic vaccines against HSV-1 and HSV-2 has met with limited success. This review provides an overview of the successes and failures, the different types of immune responses elicited by various vaccine modalities, and the need to reconsider the preclinical models and immune correlates of protection against HSV.

中文翻译：

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阿尔法疱疹病毒疫苗。


用于包括水痘带状疱疹病毒 (VZV) 和 1 型和 2 型单纯疱疹病毒在内的 α 疱疹病毒的预防性和治疗性疫苗一直是大量临床前和临床研究的焦点。用于预防水痘的活病毒疫苗和用于预防带状疱疹的亚单位治疗性疫苗非常成功。相比之下，针对 HSV-1 和 HSV-2 的有效预防性或治疗性疫苗的开发取得的进展有限。本综述概述了成功和失败、各种疫苗方式引起的不同类型的免疫反应，以及重新考虑 HSV 保护的临床前模型和免疫相关性的必要性。