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Molecular mechanisms behind mRNA localization in axons.
Open Biology ( IF 5.8 ) Pub Date : 2020-09-23 , DOI: 10.1098/rsob.200177
Benita Turner-Bridger 1 , Cinzia Caterino 2 , Jean-Michel Cioni 2
Affiliation  

Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at the subcellular level. This is observed in the axons of neurons, where mRNA localization is involved in regulating neuronal development and function by orchestrating rapid adaptive responses to extracellular cues and the maintenance of axonal homeostasis through local translation. Here, we provide an overview of the key findings that have broadened our knowledge regarding how specific mRNAs are trafficked and localize to axons. In particular, we review transcriptomic studies investigating mRNA content in axons and the molecular principles underpinning how these mRNAs arrived there, including cis-acting mRNA sequences and trans-acting proteins playing a role. Further, we discuss evidence that links defective axonal mRNA localization and pathological outcomes.



中文翻译:

轴突中 mRNA 定位背后的分子机制。

信使 RNA (mRNA) 定位允许在亚细胞水平上对蛋白质组进行时空调节。这在神经元的轴突中观察到,其中 mRNA 定位参与调节神经元发育和功能,通过协调对细胞外线索的快速适应性反应和通过局部翻译维持轴突稳态。在这里,我们概述了关键发现,这些发现拓宽了我们关于特定 mRNA 如何被贩运和定位到轴突的知识。特别是,我们回顾了研究轴突中 mRNA 含量的转录组学研究以及支持这些 mRNA 如何到达那里的分子原理,包括顺式作用 mRNA 序列和反式作用蛋白发挥作用。此外,我们讨论了将有缺陷的轴突 mRNA 定位与病理结果联系起来的证据。

更新日期:2020-09-23
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