In ornamental fisheries, body ornamentation, including the body colour, is of great economic importance. Melanocortin-1 receptor (MC1R) gene is primarily responsible for pigmentation in the majority of the vertebrates, and its modulation will help to understand the pigmentation and external body coloration. The present study was aimed to predict the MC1R tertiary protein structure of Tetraodon nigroviridis through homology modelling and to identify putative modulators. The tertiary protein structure of the MC1R protein of T. nigroviridis was homology modelled and validated. BLAHtetrone with binding efficiency of -9.7 kcal/mol was identified as a putative modulator of the MC1R protein.

中文翻译：

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黑嘴猴四肢黑皮质素-1受体（MC1R）蛋白的计算模型和天然化合物作为推定调节剂的鉴定。

在观赏性渔业中，包括肤色在内的身体装饰在经济上具有重要意义。Melanocortin-1受体（MC1R）基因主要负责大多数脊椎动物的色素沉着，其调节将有助于了解色素沉着和体外色素。本研究旨在通过同源性建模来预测黑纹四角兽的MC1R三级蛋白质结构，并确定推定的调节剂。对黑热疫病菌MC1R蛋白的三级蛋白结构进行了建模和验证。结合效率为-9.7 kcal / mol的BLAHtetron被确定为MC1R蛋白的推定调节剂。