In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia,RSC Chemical Biology

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In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
RSC Chemical Biology Pub Date : 2020-09-23 , DOI: 10.1039/d0cb00140f
Sophie V. Morse _{1,

2,

3,

4} , Tamara Boltersdorf _{2,

3,

4,

5,

6} , Tiffany G. Chan _{1,

2,

3,

4,

5} , Felicity N. E. Gavins _{4,

7,

8,

9} , James J. Choi _{1,

2,

3,

4} , Nicholas J. Long _{2,

3,

4,

5,

6}

Affiliation

To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.

中文翻译：

使用聚焦超声和微泡对激活的小胶质细胞成像的荧光FPR2 / ALX靶向探针的体内递送

为了对活化的小胶质细胞成像，使用聚焦的超声和微泡将小分子FPR2 / ALX靶向荧光探针局部递送至大脑。该探针未与神经元或星形胶质细胞共定位，而是积聚在活化的小胶质细胞中，这使其成为潜在的成像工具，可用于未来针对神经系统疾病的药物发现计划。

更新日期：2020-11-03

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