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Analysis of sequence-defined oligomers through Advanced Polymer Chromatography™ – mass spectrometry hyphenation
RSC Advances ( IF 3.9 ) Pub Date : 2020-9-23 , DOI: 10.1039/d0ra06419j Marie-Theres Berg 1 , Chiel Mertens 2 , Filip Du Prez 2 , Thomas D Kühne 1 , Artjom Herberg 1 , Dirk Kuckling 1
RSC Advances ( IF 3.9 ) Pub Date : 2020-9-23 , DOI: 10.1039/d0ra06419j Marie-Theres Berg 1 , Chiel Mertens 2 , Filip Du Prez 2 , Thomas D Kühne 1 , Artjom Herberg 1 , Dirk Kuckling 1
Affiliation
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In recent years, sequence-defined oligomers have attracted increasing interest in the polymer community and the number of new applications such as macromolecular data storage and encryption is increasing. However, techniques allowing sequence differentiation are still lacking. In this study, the focus is put towards a new strategy allowing structural distinction between sequence-defined oligomers with identical molecular weight and composition, but bearing different sequences. This technique relies on the hyphenation of size exclusion chromatography and mass spectrometry, coupled with ion mobility separation. This approach allows for a quick and easy separation and identification of oligomers with different length and/or sequence.
中文翻译：
通过 Advanced Polymer Chromatography™ 分析序列定义的寡聚物 – 质谱联用
近年来，序列定义的低聚物引起了聚合物界越来越多的兴趣，并且大分子数据存储和加密等新应用的数量不断增加。然而，仍然缺乏允许序列区分的技术。在这项研究中，重点是一种新的策略，允许具有相同分子量和组成但具有不同序列的序列定义的低聚物之间的结构区分。该技术依赖于尺寸排阻色谱法和质谱法的联用，以及离子淌度分离。这种方法可以快速、轻松地分离和鉴定具有不同长度和/或序列的寡聚物。
更新日期：2020-09-23
中文翻译：
通过 Advanced Polymer Chromatography™ 分析序列定义的寡聚物 – 质谱联用
近年来，序列定义的低聚物引起了聚合物界越来越多的兴趣，并且大分子数据存储和加密等新应用的数量不断增加。然而，仍然缺乏允许序列区分的技术。在这项研究中，重点是一种新的策略，允许具有相同分子量和组成但具有不同序列的序列定义的低聚物之间的结构区分。该技术依赖于尺寸排阻色谱法和质谱法的联用，以及离子淌度分离。这种方法可以快速、轻松地分离和鉴定具有不同长度和/或序列的寡聚物。
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