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Spectroscopic and chromatographic investigation of chiral interactions between tiaprofenic acid and alginate–metal-complexes
RSC Advances ( IF 3.9 ) Pub Date : 2020-9-23 , DOI: 10.1039/d0ra07665a Ghaidaa Alkhayer 1 , Hussein Khudr 2 , Yahia Koudsi 1
RSC Advances ( IF 3.9 ) Pub Date : 2020-9-23 , DOI: 10.1039/d0ra07665a Ghaidaa Alkhayer 1 , Hussein Khudr 2 , Yahia Koudsi 1
Affiliation
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Alginate–metal-complexes of Ca, Ba, Zn, Fe and Al were prepared in the form of beads. The preparation was based on the ionotropic method to obtain blank beads (unloaded) and beads loaded with tiaprofenic acid. IR spectra of blank beads, drug loaded beads and physical mixtures of the drug with the blank beads were recorded. The comparison of these spectra, especially in the region of hydroxyl group, implied chiral interactions between the drug and the complexes. Additionally, the drug was released from the loaded beads in aqueous phosphate buffer solutions (PBS) at pH = 7.4. Chiral HPLC was used to determine the enantiomeric excess, % ee, of the released drug. The determined % ee values indicated chiral interactions between tiaprofenic acid and alginate–metal-complexes. However, various mathematical models were used to simulate the release kinetics for each enantiomer. The metal content of Na, Ca, Ba, Zn, Fe and Al in the studied materials was measured using atomic absorption spectroscopy.
中文翻译：
噻洛芬酸与海藻酸盐-金属配合物之间手性相互作用的光谱和色谱研究
以珠粒形式制备 Ca、Ba、Zn、Fe 和 Al 的藻酸盐-金属络合物。该制备基于离子型方法以获得空白珠粒（未加载）和负载有噻洛芬酸的珠粒。记录空白珠、载药珠和药物与空白珠的物理混合物的红外光谱。这些光谱的比较，特别是在羟基区域，暗示了药物和复合物之间的手性相互作用。此外，在 pH = 7.4 的磷酸盐缓冲溶液 (PBS) 中，药物从加载的珠子中释放出来。手性 HPLC 用于确定释放药物的对映体过量，% ee。确定的 % ee 值表明噻洛芬酸和藻酸盐-金属配合物之间的手性相互作用。然而，各种数学模型用于模拟每种对映体的释放动力学。使用原子吸收光谱法测量了研究材料中 Na、Ca、Ba、Zn、Fe 和 Al 的金属含量。
更新日期：2020-09-23
中文翻译：
噻洛芬酸与海藻酸盐-金属配合物之间手性相互作用的光谱和色谱研究
以珠粒形式制备 Ca、Ba、Zn、Fe 和 Al 的藻酸盐-金属络合物。该制备基于离子型方法以获得空白珠粒（未加载）和负载有噻洛芬酸的珠粒。记录空白珠、载药珠和药物与空白珠的物理混合物的红外光谱。这些光谱的比较，特别是在羟基区域，暗示了药物和复合物之间的手性相互作用。此外，在 pH = 7.4 的磷酸盐缓冲溶液 (PBS) 中，药物从加载的珠子中释放出来。手性 HPLC 用于确定释放药物的对映体过量，% ee。确定的 % ee 值表明噻洛芬酸和藻酸盐-金属配合物之间的手性相互作用。然而，各种数学模型用于模拟每种对映体的释放动力学。使用原子吸收光谱法测量了研究材料中 Na、Ca、Ba、Zn、Fe 和 Al 的金属含量。
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