Dielectric microsphere based super-resolution imaging is a promising approach to overcome the diffraction limit of imaging in an optical microscope. So far, it still remains as a challenge to efficiently implement super-resolution imaging in a large area in a controlled manner. In this study, a home-designed imaging probe which consists of a microsphere array is applied to implement scanning of sample surfaces with an enhanced imaging resolution. The individually scanned images from different microspheres can then be stitched together to construct a large area super-resolution optical image. The experimental results show that the proposed method can correctly stitch together individually scanned images, leading to efficient and feasible super-resolution imaging in an imaging area of 195 μ m × 150 μ m.

中文翻译：

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扫描微球阵列光学显微镜，用于高效和大面积超分辨率成像

基于介电微球的超分辨率成像是一种有前途的方法，可以克服光学显微镜中成像的衍射极限。迄今为止，以大面积有效地以受控方式实现超分辨率成像仍然是一个挑战。在这项研究中，由微球阵列组成的家庭设计的成像探针可用于以增强的成像分辨率进行样品表面扫描。然后可以将来自不同微球的单独扫描的图像缝合在一起，以构建大面积的超分辨率光学图像。实验结果表明，该方法可以正确地将单独扫描的图像拼接在一起，从而在195μm×150μm的成像区域中实现高效可行的超分辨率成像。