Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-Cell Proliferation from a Mangrove Endophytic Fungus.,Journal of Natural Products

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Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-Cell Proliferation from a Mangrove Endophytic Fungus.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-09-23 , DOI: 10.1021/acs.jnatprod.0c00535
Qi Gan ₁ , Chunyu Lin _{2,

3} , Changjun Lu ₁ , Yimin Chang ₁ , Qian Che ₁ , Guojian Zhang _{1,

4} , Tianjiao Zhu _{1,

4} , Qianqun Gu ₁ , Zhiqiang Wu ₃ , Mingyu Li ₂ , Dehai Li _{1,

4}

Affiliation

This project was focused on the discovery of novel compounds that promote endogenous β-cell regeneration. Screening of extracts identified the fungus Stachybotrys chartarum as a promising candidate. After fermentation and extraction of S. chartarum, we isolated five new prenylated xanthones, namely, staprexanthones A–E (1–5), with staprexanthone A (1) being the first natural xanthone bearing a rare 4,5-dimethyl-1,3-dioxolane moiety. Compounds 1, 2, and 5 significantly increased β-cell numbers in vivo in a zebrafish model. Further analysis revealed that 2 and 5 promoted β-cell mass expansion by increasing proliferation of existing β-cells though promotion of cell-cycle progression at the G1/S transition. These findings indicate that prenylated xanthones are potential new drug leads for antidiabetes therapy by stimulating β-cell regeneration.

中文翻译：

Staprexantones，来自红树林内生真菌的胰腺 β 细胞增殖的呫吨酮型刺激剂。

该项目的重点是发现促进内源性 β 细胞再生的新型化合物。提取物的筛选确定真菌Stachybotrys chartarum为有希望的候选者。S. chartarum发酵和提取后，我们分离出了五种新的异戊二烯化氧杂蒽酮，即 staprexantones A–E ( 1 – 5 )，其中 staprexantones A ( 1 ) 是第一个带有稀有 4,5-二甲基-1 的天然氧杂蒽酮， 3-二氧戊环部分。化合物1，2，和5显著增加β细胞数量在体内在斑马鱼的模型。进一步的分析表明2和5通过在 G1/S 过渡时促进细胞周期进程，通过增加现有 β 细胞的增殖来促进 β 细胞质量扩张。这些发现表明异戊二烯化氧杂蒽酮是通过刺激 β 细胞再生进行抗糖尿病治疗的潜在新药。

更新日期：2020-10-26

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