Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. We measured the expression levels of proatherogenic inflammatory/antiatherogenic inflammatory cytokines. This included interleukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-17 (IL-17), interleukin-13 (IL-13), and interleukin-37 (IL-37) in the elderly patients with the proximal, middle, and distal coronary artery reocclusions after coronary stent implantations. Levels of IL-1 β, IL-6, IL-8, TNF-α, and hs-CRP were remarkably increased (), and levels of IL-10, IL-17, IL-13, and IL-37 were remarkably lowered () in the elderly patients with the proximal, middle, and distal coronary artery reocclusions. Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators may be involved in the formation and progression of proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations.

中文翻译：

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促炎和抗炎介质水平改变对老年患者支架内再闭塞位置的影响

致动脉粥样硬化炎症介质和抗动脉粥样硬化炎症介质的失衡参与了动脉粥样硬化的发病机制。本研究旨在探讨促动脉粥样硬化炎症介质和抗动脉粥样硬化炎症介质对冠状动脉支架植入术后老年患者冠状动脉近端、中端和远端再闭塞的影响。我们测量了促动脉粥样硬化炎症/抗动脉粥样硬化炎症细胞因子的表达水平。这包括白介素-1 β (IL-1 β )、白介素-6 (IL-6)、白介素-8 (IL-8)、肿瘤坏死因子-α (TNF- α))、高敏 C 反应蛋白 (hs-CRP)、白介素-10 (IL-10)、白介素-17 (IL-17)、白介素-13 (IL-13) 和白介素-37 (IL-37) ) 用于冠状动脉支架植入术后近端、中端和远端冠状动脉再闭塞的老年患者。IL- 1β、IL-6、IL-8、TNF- α和hs-CRP水平显着升高（)，并且 IL-10、IL-17、IL-13 和 IL-37 的水平显着降低（)用于近端、中端和远端冠状动脉再闭塞的老年患者。冠状动脉支架植入术后老年患者冠状动脉近端、中端和远端再闭塞的形成和进展可能涉及促动脉粥样硬化炎症介质和抗动脉粥样硬化炎症介质的失衡。