Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). We have investigated the number and lineage-specific clusters of differentiation (CD) expression of the atypical mononuclear cells in 110 children with IM using the anti-CD antibody microarray for panning the leukocytes by their surface markers prior to morphology examination. We show that AM population consists primarily of CD8+ T-cells with a small fraction (0-2% of all lymphocytes) of CD19+ B-lymphocytes. The AM amount in children with mononucleosis caused by primary EBV infection was significantly higher than for IM caused by EBV reactivation or other viruses and constituted 1-53% from all peripheral blood mononuclear cells compared to 0-11% and 0-8% respectively. The children failing to recover from classic IM associated with primary EBV infection in 6 months were found to have significantly lower percentage of CD8+ AM compared to the patients with normal recovery rate.

中文翻译：

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儿童 Epstein-Barr 病毒引起的传染性单核细胞增多症中非典型单核细胞的性质和临床意义。

爱泼斯坦-巴尔病毒 (EBV) 相关传染性单核细胞增多症 (IM) 患者的外周血中大量出现非典型单核细胞 (AM)。我们研究了 110 名 IM 儿童中非典型单核细胞的数量和谱系特异性分化簇 (CD) 表达，使用抗 CD 抗体微阵列在形态学检查之前通过其表面标志物淘选白细胞。我们表明 AM 群体主要由 CD8+ T 细胞和一小部分（所有淋巴细胞的 0-2%）CD19+ B 淋巴细胞组成。由原发性 EBV 感染引起的单核细胞增多症儿童的 AM 量显着高于由 EBV 再激活或其他病毒引起的 IM，占所有外周血单个核细胞的 1-53%，而分别为 0-11% 和 0-8%。