An active loop-extrusion mechanism is regarded as the main out-of-equilibrium mechanism responsible for the structuring of megabase-sized domains in chromosomes. We developed a model to study the dynamics of the chromosome fiber by solving the kinetic equations associated with the motion of the extruder. By averaging out the position of the extruder along the chain, we build an effective equilibrium model capable of reproducing experimental contact maps based solely on the positions of extrusion-blocking proteins. We assessed the quality of the effective model using numerical simulations of chromosomal segments and comparing the results with explicit-extruder models and experimental data.

中文翻译：

---

环挤出的有效模型可预测染色体结构域

主动环挤出机制被认为是主要的失衡机制，负责染色体中兆碱基大小域的结构化。我们开发了一个模型，通过求解与挤出机运动相关的动力学方程来研究染色体纤维的动力学。通过平均挤出机沿链的位置，我们建立了一个有效的平衡模型，该模型能够仅基于挤出阻断蛋白的位置来复制实验接触图。我们使用染色体区段的数值模拟并将结果与​​显式挤出机模型和实验数据进行了比较，从而评估了有效模型的质量。