Microglia are the brain resident immune cells; they can produce a large variety of growth factors (GFs) to prevent neuronal damages and promote recovery. In neurodegenerative diseases, microglia can play both benefic and deleterious roles, depending on different factors and disease context. In multiple sclerosis, microglia are involved in both demyelination (DM) and remyelination (RM) processes. Recent studies suggest a beneficial role of microglia in regenerative processes. These include the regenerative development of myelin after DM. This review gives an overlook of how microglia and GFs can influence the RM properties.

中文翻译：

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小胶质细胞和生长因子在MS中的有益作用，简述

小胶质细胞是大脑中的免疫细胞。它们可以产生多种生长因子（GFs），以防止神经元损伤并促进恢复。在神经退行性疾病中，小胶质细胞可同时发挥有益作用和有害作用，具体取决于不同因素和疾病背景。在多发性硬化症中，小胶质细胞参与脱髓鞘（DM）和再髓鞘（RM）过程。最近的研究表明小胶质细胞在再生过程中的有益作用。这些包括DM后髓磷脂的再生发育。这篇评论忽略了小胶质细胞和GF如何影响RM特性。