Background: In the pathogenesis of intermittent allergic rhinitis (IAR), the inflammatory reaction is of importance. CD48, belonging to the CD2 family, participates in mast cell-stimulating cross-talk, facilitates the formation of the mast cell/eosinophil effector unit, and is expressed by eosinophils. Objectives: To assess the serum level of soluble form of CD48 (sCD48) in patients with IAR during and out of the pollen season and correlate with the disease severity and with eosinophil-related parameters. Materials and Methods: Sixty-three patients (female: 79%; mean age: 30.58) were included to the study. Forty-five patients were assessed during the pollen season and other 42 patients during out of the pollen season. Twenty-four patients (female: 37.50%; mean age: 27.90) were evaluated twice, during the pollen season and out of the pollen season. sCD48, ECP, eotaxin-1/CCL11 serum levels together with complete blood count, and fractional exhaled nitric oxide bronchial and nasal fraction (FeNO) were performed. The severity of symptoms was assessed using the Total Nasal Symptom Score (TNSS), and neutrophil-to-lymphocyte (NLR) and eosinophil-to-lymphocyte (ELR) ratios were calculated. Results: sCD48 serum level, FeNO nasal and bronchial fractions, and TNSS were significantly higher in the IAR group in the pollen season compared with out of the pollen season. Differences in ECP, eotaxin-1/CCL11 serum levels, and NLR and ELR were not significant between season and out of the season. No correlations were found between sCD48 and eosinophil-related parameters. Conclusions: sCD48 may be a biomarker to the exacerbation phase in patients with IAR. One can assume that CD48 participates in the pathogenesis of IAR.
Int Arch Allergy Immunol

中文翻译：

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间歇性过敏性鼻炎患者血清 CD48 水平升高。

背景：在间歇性变应性鼻炎（IAR）的发病机制中，炎症反应具有重要意义。CD48 属于 CD2 家族，参与刺激肥大细胞的串扰，促进肥大细胞/嗜酸性粒细胞效应单元的形成，并由嗜酸性粒细胞表达。目的：评估 IAR 患者在花粉季节期间和以外的血清可溶性 CD48 (sCD48) 水平，并与疾病严重程度和嗜酸性粒细胞相关参数相关联。材料和方法：63 名患者（女性：79%；平均年龄：30.58）被纳入研究。在花粉季节对 45 名患者进行了评估，在花粉季节之外对其他 42 名患者进行了评估。24 名患者（女性：37.50%；平均年龄：27.90）在花粉季节和花粉季节外接受了两次评估。进行了 sCD48、ECP、eotaxin-1/CCL11 血清水平以及全血细胞计数和呼出气一氧化氮支气管和鼻部分数 (FeNO)。使用总鼻症状评分 (TNSS) 评估症状的严重程度，并计算中性粒细胞与淋巴细胞 (NLR) 和嗜酸性粒细胞与淋巴细胞 (ELR) 的比率。结果：与非花粉季节相比，花粉季节 IAR 组的 sCD48 血清水平、FeNO 鼻和支气管组分和 TNSS 显着升高。ECP、eotaxin-1/CCL11 血清水平以及 NLR 和 ELR 的差异在季节和季节之间不显着。在 sCD48 和嗜酸性粒细胞相关参数之间没有发现相关性。结论： sCD48 可能是 IAR 患者恶化阶段的生物标志物。可以假设 CD48 参与了 IAR 的发病机制。
Int Arch 过敏免疫