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The Application of Porphyrins and Their Analogues for Inactivation of Viruses
Molecules ( IF 4.2 ) Pub Date : 2020-09-23 , DOI: 10.3390/molecules25194368
Natalya Sh. Lebedeva , Yury A. Gubarev , Mikhail O. Koifman , Oskar I. Koifman

The problem of treating viral infections is extremely relevant due to both the emergence of new viral diseases and to the low effectiveness of existing approaches to the treatment of known viral infections. This review focuses on the application of porphyrin, chlorin, and phthalocyanine series for combating viral infections by chemical and photochemical inactivation methods. The purpose of this review paper is to summarize the main approaches developed to date in the chemical and photodynamic inactivation of human and animal viruses using porphyrins and their analogues and to analyze and discuss the information on viral targets and antiviral activity of porphyrins, chlorins, of their conjugates with organic/inorganic compounds obtained in the last 10–15 years in order to identify the most promising areas.

中文翻译:

卟啉及其类似物在病毒灭活中的应用

由于新病毒疾病的出现和现有治疗已知病毒感染的方法的低效率,治疗病毒感染的问题极为相关。本综述重点介绍卟啉、二氢卟酚和酞菁系列在通过化学和光化学灭活方法对抗病毒感染中的应用。这篇综述论文的目的是总结迄今为止在使用卟啉及其类似物化学和光动力学灭活人类和动物病毒方面的主要方法,并分析和讨论有关病毒靶点和卟啉、二氢卟酚、二氢卟酚的抗病毒活性的信息。将它们与过去 10-15 年获得的有机/无机化合物结合,以确定最有前途的领域。
更新日期:2020-09-23
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