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Brain and COVID-19 Crosstalk: Pathophysiological and Psychological Manifestations
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-22 , DOI: 10.1021/acschemneuro.0c00446 Kalyani Verma 1 , Amitabh 1 , Dipti N. Prasad 1 , Bhuvnesh Kumar 2 , Ekta Kohli 3
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-22 , DOI: 10.1021/acschemneuro.0c00446 Kalyani Verma 1 , Amitabh 1 , Dipti N. Prasad 1 , Bhuvnesh Kumar 2 , Ekta Kohli 3
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The world is experiencing one of the major viral outbreaks of this millennium, caused by a plus sense single-stranded RNA virus belonging to the Coronaviridae family, COVID-19, declared as pandemic by WHO. The clinical manifestations vary from asymptomatic to mild symptoms like fever, dry cough, and diarrhea, with further increase in severity leading to the development of acute respiratory distress syndrome. Though primary manifestations are respiratory and cardiac, various studies have shown the neuroinvasive capability of this virus resulting in neurological complications, which sometimes can precede common typical symptoms like fever and cough. Common neurological symptoms are headache, dizziness, anosmia, dysgeusia, confusion, and muscle weakening, progressing toward severe complications like cerebrovascular disease, seizures, or paralysis. Older adults and critically ill people are in the high risk group and have shown severe neurological symptoms upon infection. COVID-19 also has a profound impact on the mental health of people across the world. In this review, we briefly discuss the neurological pathologies and psychological impact due to COVID-19, which has not only stressed the physical health of people but has also created social and economic problems resulting in mental health issues.
中文翻译：
脑和COVID-19串扰：病理生理和心理表现
世界正遭受本千年的主要病毒暴发之一，这种暴发是由属于冠状病毒科COVID-19的正向单链RNA病毒引起的，被世界卫生组织宣布为大流行。临床表现从无症状到轻度症状，如发烧，干咳和腹泻，其严重程度进一步提高，导致发展为急性呼吸窘迫综合征。尽管主要表现是呼吸和心脏疾病，但各种研究表明该病毒具有神经侵袭能力，可导致神经系统并发症，有时可先发烧和咳嗽等常见典型症状。常见的神经系统症状是头痛，头晕，失眠，消化不良，意识模糊和肌肉无力，发展为严重的并发症，如脑血管疾病，癫痫发作或瘫痪。老年人和重症患者属于高危人群，感染后表现出严重的神经系统症状。COVID-19还对全世界人们的心理健康产生深远影响。在这篇综述中，我们简要讨论了由于COVID-19引起的神经病理学和心理影响，COVID-19不仅强调了人们的身体健康，而且还造成了导致心理健康问题的社会和经济问题。
更新日期：2020-10-21
中文翻译：
脑和COVID-19串扰：病理生理和心理表现
世界正遭受本千年的主要病毒暴发之一，这种暴发是由属于冠状病毒科COVID-19的正向单链RNA病毒引起的，被世界卫生组织宣布为大流行。临床表现从无症状到轻度症状，如发烧，干咳和腹泻，其严重程度进一步提高，导致发展为急性呼吸窘迫综合征。尽管主要表现是呼吸和心脏疾病，但各种研究表明该病毒具有神经侵袭能力，可导致神经系统并发症，有时可先发烧和咳嗽等常见典型症状。常见的神经系统症状是头痛，头晕，失眠，消化不良，意识模糊和肌肉无力，发展为严重的并发症，如脑血管疾病，癫痫发作或瘫痪。老年人和重症患者属于高危人群，感染后表现出严重的神经系统症状。COVID-19还对全世界人们的心理健康产生深远影响。在这篇综述中，我们简要讨论了由于COVID-19引起的神经病理学和心理影响，COVID-19不仅强调了人们的身体健康，而且还造成了导致心理健康问题的社会和经济问题。
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