Abstract

A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1–5 were evaluated for their anti-inflammatory activities against the nitric oxide (NO) production, and compounds 1–5 showed moderate inhibitory activities with IC₅₀ values ranging from 16.15 to 27.08 µM.

摘要

从红树林内生真菌Aspergillus sp.中分离出一种新的倍半萜、gxsespene A (1) 和四种已知的倍半萜衍生物2-5 。GXNU-MA1。基于高分辨率电喷雾电离质谱 (HR-ESI-MS) 数据、广泛的核磁共振 (NMR) 光谱分析以及与文献数据的比较，阐明了它们的结构。通过单晶X射线衍射分析进一步证实了1的结构，建立了1的绝对构型。评估了化合物1-5对一氧化氮 (NO) 产生的抗炎活性，化合物1-5显示出中等抑制活性，IC ₅₀值范围为 16.15 至 27.08  µM。