Catalytic Enantioselective Bromoaminocyclization and Bromocycloetherification,Advanced Synthesis & Catalysis

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Catalytic Enantioselective Bromoaminocyclization and Bromocycloetherification
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-09-22 , DOI: 10.1002/adsc.202000845
Haitao Wang ₁ , Haijing Zhong ₁ , Xi Xu ₁ , Wei Xu ₁ , Xiaojian Jiang ₂

Affiliation

We apply a chiral anionic phase‐transfer system for the catalytic asymmetric bromoaminocyclization and bromocycloetherification of momo‐functional benzo‐cyclic alkenes. Various brominated tricyclic benzo‐heterocycles were produced with up to 99% yields and 99% enantiomeric excess. The resulting enantioenriched hexahydro‐benzoindoles are key building blocks of bioactive molecules.

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