Recent Advancements on Transition‐Metal‐Catalyzed, Chelation‐Induced ortho‐Hydroxylation of Arenes,Advanced Synthesis & Catalysis

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Recent Advancements on Transition‐Metal‐Catalyzed, Chelation‐Induced ortho‐Hydroxylation of Arenes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-09-22 , DOI: 10.1002/adsc.202000762
Zafar Iqbal ₁ , Asha Joshi ₁ , Saroj De ₁

Affiliation

The phenols are key intermediates as well as desired products in many target oriented syntheses. The conversion of C−H bond to C−O bond is one of the most challenging tasks in organic synthesis. In last few decades, the hydroxylation of aromatic compounds has drawn a considerable attention because of their importance in Pharmaceutical industry, material chemistry, polymers and in agrochemicals. Indeed, transition‐metal‐catalyzed, coordination‐assisted regio‐ and chemoselective ortho‐hydroxylation of arenes has become very efficient and popular strategy to obtain good yields of phenols with tolerance of a wide range of functional groups. This review is the comprehensive summary of recent advancement on Pd‐, Ru‐, Rh‐, Cu‐ and Ir‐catalyzed, chelation‐controlled regioselective ortho‐C−H bond hydroxylation of aromatic compounds in the presence of diverse hydroxylating agents. The review has been classified on the sources of hydroxylating agents used in reaction.

中文翻译：

芳烃的过渡金属催化，螯合诱导的邻羟基氧化的最新进展

苯酚是许多目标定向合成中的关键中间体以及所需产品。CH键到CO键的转化是有机合成中最具挑战性的任务之一。在过去的几十年中，由于芳香族化合物的羟基化在制药工业，材料化学，聚合物和农用化学品中的重要性，因此引起了相当大的关注。的确，芳烃的过渡金属催化，配位辅助的区域和化学选择性邻羟基化反应已成为非常有效和流行的策略，可获得良好的苯酚收率并具有广泛的官能团耐受性。这篇综述是对Pd，Ru，Rh，Cu和Ir催化，螯合控制的区域选择性邻位的最新进展的全面总结。在各种羟基化剂存在下芳香族化合物的‐ C−H键羟基化。综述已将反应中使用的羟基化剂的来源分类。

更新日期：2020-09-22

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