Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: Preliminary screening and comprehensive functional analysis.,FEBS Open Bio

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Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: Preliminary screening and comprehensive functional analysis.
FEBS Open Bio ( IF 2.8 ) Pub Date : 2020-09-23 , DOI: 10.1002/2211-5463.12981
Yang Liu _{1,

2} , Zhencheng Li _{1,

2} , Jianheng Hao _{1,

2} , Hao Chen _{1,

2} , Tiezheng Hou _{1,

2} , Huiqin Hao _{1,

2}

Affiliation

Without treatment, autoimmune hepatitis (AIH) often leads to cirrhosis, liver failure and, in some cases, death. However, the pathogenesis of AIH remains incompletely understood. Here, we explored the relationship between differentially expressed circular RNAs (DECs) and development of AIH by obtaining an expression profile of DECs in a concanavalin A‐induced AIH mouse model by microarray. In total, we identified 27 DECs; the host genes of these DECs were annotated with 140 Gene Ontology terms and 19 pathways, revealing potential roles in the metabolism of cellular ions and regulation of protein expression, as well as possible involvement in endocytosis and apoptosis. We constructed a circular RNA–microRNA network that was used to infer that a mmu_circ_0001520/mmu‐miR‐193b‐3p/MAPK10 network may be associated with the occurrence of AIH. These findings may help lay the foundation for validation of the potential roles of circular RNAs in AIH.

中文翻译：

与刀豆蛋白 A 诱导的自身免疫性肝炎小鼠模型相关的环状 RNA：初步筛选和综合功能分析。

如果不进行治疗，自身免疫性肝炎 (AIH) 通常会导致肝硬化、肝功能衰竭，在某些情况下甚至会导致死亡。然而，AIH 的发病机制仍不完全清楚。在这里，我们通过微阵列获得刀豆蛋白 A 诱导的 AIH 小鼠模型中 DECs 的表达谱，探讨了差异表达的环状 RNA (DECs) 与 AIH 发展之间的关系。我们总共确定了 27 个 DEC；这些DECs的宿主基因用140个基因本体术语和19个途径进行注释，揭示了在细胞离子代谢和蛋白质表达调节中的潜在作用，以及可能参与内吞作用和细胞凋亡。我们构建了一个环状 RNA-microRNA 网络，用于推断mmu_circ_0001520/mmu-miR-193b-3p/MAPK10网络可能与AIH的发生有关。这些发现可能有助于为验证环状 RNA 在 AIH 中的潜在作用奠定基础。

更新日期：2020-11-04

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