Site- and structure-specific characterization of human urinary N-glycoproteome with site-determining and structure-diagnostic product ions.,Rapid Communications in Mass Spectrometry

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Site- and structure-specific characterization of human urinary N-glycoproteome with site-determining and structure-diagnostic product ions.
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-09-23 , DOI: 10.1002/rcm.8952
Yun Shen ₁ , Kaijie Xiao ₁ , Zhixin Tian ₁

Affiliation

N‐glycosylation is one of the most common protein post‐translational modifications; it is extremely complex with multiple glycoforms from different monosaccharide compositions, sequences, glycosidic linkages, and anomeric positions. Each glycoform functions with a particular site‐ and structure‐specific N‐glycan that can be fully characterized using state‐of‐the‐art tandem mass spectrometry (MS/MS) and the intact N‐glycopeptide database search engine GPSeeker that we recently developed. Urine has recently gained increasing attention as a non‐invasive source for disease marker discovery. In this study, we report our structure‐specific N‐glycoproteomics study of human urine.

中文翻译：

具有位点确定和结构诊断产物离子的人尿 N-糖蛋白质组的位点和结构特异性表征。

N-糖基化是最常见的蛋白质翻译后修饰之一；它具有来自不同单糖组成、序列、糖苷键和异头位置的多种糖型极其复杂。每个糖型都具有特定的位点和结构特异性 N-聚糖，可以使用最先进的串联质谱 (MS/MS) 和我们最近开发的完整 N-糖肽数据库搜索引擎 GPSeeker 对其进行全面表征. 尿液作为疾病标志物发现的非侵入性来源，最近越来越受到关注。在这项研究中，我们报告了我们对人类尿液的结构特异性 N-糖蛋白质组学研究。

更新日期：2020-11-09

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