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Synthetic Antibody Mimics Based on Cancer‐Targeting Immunostimulatory Peptides
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/cbic.202000407 Dante Descalzi-Montoya 1 , Rachel A Montel 2 , Keith Smith 2 , Eugenia Dziopa 1 , Andrieh Darwich 2 , Zheng Yang 1 , Constantine Bitsaktsis 2 , Robert Korngold 1 , David Sabatino 2
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/cbic.202000407 Dante Descalzi-Montoya 1 , Rachel A Montel 2 , Keith Smith 2 , Eugenia Dziopa 1 , Andrieh Darwich 2 , Zheng Yang 1 , Constantine Bitsaktsis 2 , Robert Korngold 1 , David Sabatino 2
Affiliation
Immunotherapy and insights: De novo cancer‐targeting immunostimulatory peptides bind to surface GRP78 on tumors and the NKp30 receptor on NK cells for anti‐tumor immunostimulatory activity in vitro and in vivo. This study underscores the proof‐of‐concept discovery of a synthetic peptide that can mimic the targeting and activating functions of antibodies while facilitating NK‐dependent cancer immunotherapy.
中文翻译:
基于癌症靶向免疫刺激肽的合成抗体模拟物
免疫疗法和见解:从头癌症靶向免疫刺激肽与肿瘤表面 GRP78 和 NK 细胞上 NKp30 受体结合,在体外和体内发挥抗肿瘤免疫刺激活性。这项研究强调了一种合成肽的概念验证发现,它可以模拟抗体的靶向和激活功能,同时促进 NK 依赖性癌症免疫治疗。
更新日期:2020-09-22
中文翻译:
基于癌症靶向免疫刺激肽的合成抗体模拟物
免疫疗法和见解:从头癌症靶向免疫刺激肽与肿瘤表面 GRP78 和 NK 细胞上 NKp30 受体结合,在体外和体内发挥抗肿瘤免疫刺激活性。这项研究强调了一种合成肽的概念验证发现,它可以模拟抗体的靶向和激活功能,同时促进 NK 依赖性癌症免疫治疗。