Introduction of lithium carbonate to treat manic excitement in 1949 by John Cade in Melbourne opened a new, revolutionary era in psychiatry with the first clinically effective pharmacological treatment for a major psychiatric disorder. By 1960, there followed explosive discovery and development of at least one of every class of psychotropic medicines currently available.¹ Further development of lithium as a safe and effective treatment for bipolar disorder (BD), both for acute mania and reduction of risk of recurrences of mania and bipolar depression was led by Mogens Schou in Denmark, following the initial report of long‐term protective effects by Cade.

中文翻译：

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锂治疗双相情感障碍。

我碳酸锂导论由约翰·卡德在墨尔本治疗狂躁激动于1949年在精神病学开辟了新的，革命性的时代与第一临床有效药物治疗的一个主要的精神疾病。到1960年，随之而来的是爆炸性发现和开发了目前可用的每种精神药物中的至少一种。¹在长期保护的初步报告之后，丹麦的Mogens Schou领导了锂的进一步开发，将其作为一种安全有效的双相情感障碍（BD）疗法，用于治疗急性躁狂和降低躁狂复发和躁郁症复发的风险。 Cade的效果。