The addition of biomaterials such as Calcium Hydroxyapatite (cHAp) and incorporation of porosity into poly-ether-ether-ketone (PEEK) are effective ways to improve bone-implant interfaces and osseointegration of PEEK composite. Hence, the morphological effects of nanocomposite on surfaces biocompatibility of a newly fabricated composite of PEEK polymer and cHAp for a bone implant, using additive manufacturing (AM) were investigated. Fused deposition modeling (FDM) method and a surface treatment strategy were employed to create a microporous scaffold. PEEK osteointegration was slow and, therefore, it was accelerated by surface coatings with the incorporation of bioactive cHAp, with enhanced mechanical and biological behaviors for bone implants. Characterization of the new PEEK/cHAp composite was done by X-ray diffraction (XRD), differential scanning calorimetry (DSC), mechanical tests of traction and flexion, thermal dynamic mechanical analysis (DMA). Also, the PEEK/cHAp induced the formation of apatite after immersion in the simulated body fluid of DMEM for different days to check its biological bioactivity for an implant. In-vivo results depicted that the osseointegration and the biological activity around the PEEK/cHAp composite were higher than that of PEEK. The increase in the mechanical performance of cHAp-coated PEEK can be attributed to the increase in the degree of crystallinity and accumulation of residual polymer.

添加生物材料，例如羟基磷灰石钙（cHAp）并将孔隙率并入聚醚醚酮（PEEK）中，是改善骨植入物界面和PEEK复合材料骨整合的有效方法。因此，使用增材制造（AM），研究了纳米复合材料对新制备的PEEK聚合物和cHAp用于骨植入物的复合材料的表面生物相容性的形态学影响。融合沉积建模（FDM）方法和表面处理策略被用来创建微孔支架。PEEK骨整合较慢，因此，通过结合生物活性cHAp的表面涂层可加快其整合速度，并增强骨骼植入物的机械和生物学行为。通过X射线衍射（XRD）对新型PEEK / cHAp复合材料进行表征，差示扫描量热法（DSC），牵引和弯曲的机械测试，热力学机械分析（DMA）。同样，PEEK / cHAp浸入DMEM模拟体液中不同天后诱导磷灰石形成，以检查其对植入物的生物活性。体内结果表明，PEEK / cHAp复合材料周围的骨整合和生物活性高于PEEK。cHAp涂层的PEEK的机械性能的提高可归因于结晶度的增加和残余聚合物的积累。PEEK / cHAp浸入DMEM模拟体液中不同天后诱导磷灰石形成，以检查其对植入物的生物活性。体内结果表明，PEEK / cHAp复合材料周围的骨整合和生物活性高于PEEK。cHAp涂层的PEEK的机械性能的提高可归因于结晶度的增加和残余聚合物的积累。PEEK / cHAp浸入DMEM模拟体液中不同天后诱导磷灰石形成，以检查其对植入物的生物活性。体内结果表明，PEEK / cHAp复合材料周围的骨整合和生物活性高于PEEK。cHAp涂层的PEEK的机械性能的提高可归因于结晶度的增加和残余聚合物的积累。