The Arp2/3 complex orchestrates the formation of branched actin networks at the interface between the cytoplasm and membranes. Although it is widely appreciated that these networks are useful for scaffolding, creating pushing forces and delineating zones at the membrane interface, it has only recently come to light that branched actin networks are mechanosensitive, giving them special properties. Here, we discuss recent advances in our understanding of how Arp2/3-generated actin networks respond to load forces and thus allow cells to create pushing forces in responsive and tuneable ways to effect cellular processes such as migration, invasion, phagocytosis, adhesion and even nuclear and DNA damage repair.

Arp2 / 3复合物在细胞质和膜之间的界面处编排支链肌动蛋白网络。尽管众所周知这些网络可用于支架，在膜界面处产生推力和勾画区域，但直到最近才发现分支肌动蛋白网络具有机械敏感性，从而赋予它们特殊的性能。在这里，我们讨论了关于Arp2 / 3-生成的肌动蛋白网络如何响应负载力的理解的最新进展，从而使细胞以响应性和可调节的方式产生推力，从而影响细胞过程，例如迁移，侵袭，吞噬作用，粘附甚至核和DNA损伤修复。