Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson’s disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS “off” and “on” conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time–frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS “on” state than in the DBS “off” state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS “on” condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.

尽管帕金森病 (PD) 中丘脑底核深部脑刺激 (STN-DBS) 通常是一种成功的治疗方法，但不良事件和临床效果不足会使某些患者的治疗复杂化。我们研究了与 STN-DBS 相关的临床参数和皮质振荡，以确定反应不佳的患者。在 32 名患有 STN-DBS 的 PD 患者的 DBS“关闭”和“开启”条件下，在视觉奇怪的三刺激范式期间记录了高密度 EEG。预处理的数据被重建到源空间，并评估时频分析。我们确定了一个由 6 名患者组成的亚组，在目标刺激后，DBS“开启”状态下的反应时间 (RT) 比 DBS“关闭”状态下的更长。与其他受试者相比，这些受试者对 DBS 的运动反应较低，记忆测试结果也较差。此外，阿尔法和贝塔功率降低（事件相关的不同步，ERD），被称为与运动和认知处理相关的激活相关，在这些患者的 DBS“开启”条件下也减少。确定了对 STN-DBS 反应不佳的 PD 患者亚组。RT 的评估可能作为对 STN-DBS 反应性的生物标志物。