This study focused on a facile and low-cost approach to synthesize La₂Fe₂O₆/PVP core/shell nanoparticles in which the La₂Fe₂O₆ can be incorporated into the polyvinylpyrrolidone (PVP). La₂Fe₂O₆ (core) was prepared as the precursor by a modified citrate technique, then the PVP (shell) was seeded to form core/shell structure at various pH conditions. The variation of pH plays an important role in controlling the morphology of the investigated samples. The structural and morphological characterization of samples were carried out using X-ray analysis and High-resolution transmission electron micrographs (HRTEM), respectively. All samples exhibit orthorhombic crystal structure with Pbnm space group. Moreover, the particles in La₂Fe₂O₆ are not stable enough and have a high tendency to aggregate and undergo rapid biodegradation in biological systems. However, La₂Fe₂O₆/PVP Core/shell has antibacterial activity against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa) by 13.0, 11.0, and 12.0 mm inhibition zone diameter (IZD), respectively. Furthermore, coating La₂Fe₂O₆ with a PVP shell optimizes nanoparticles size distribution and agglomeration. The unique magnetic properties prompt the use of the investigated samples in diverse fields.

这项研究集中于一种简便且低成本的合成La ₂ Fe ₂ O ₆ / PVP核/壳纳米粒子的方法，其中La ₂ Fe ₂ O ₆可以掺入聚乙烯吡咯烷酮（PVP）中。La ₂ Fe ₂ O ₆通过改进的柠檬酸盐技术将四氢呋喃（核）制备为前体，然后接种PVP（壳）以在各种pH条件下形成核/壳结构。pH的变化在控制所研究样品的形态方面起着重要作用。样品的结构和形态表征分别使用X射线分析和高分辨率透射电子显微照片（HRTEM）进行。所有样品均显示具有Pbnm空间群的正交晶体结构。此外，La ₂ Fe ₂ O ₆中的颗粒不够稳定，并且在生物系统中具有高聚集和快速生物降解的趋势。但是，La ₂ Fe ₂ O ₆/ PVP核/壳分别对金黄色葡萄球菌（S. aureus），大肠杆菌（E. coli）和铜绿假单胞菌（P. aeruginosa）具有13.0、11.0和12.0 mm抑制区直径（IZD）的抗菌活性。此外，用PVP壳包覆La ₂ Fe ₂ O ₆可优化纳米粒子的尺寸分布和团聚。独特的磁性能促使人们在不同领域中使用所研究的样品。