Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. Advanced glycation end product and its receptor activation, cardiac energy dysmetabolism, structural and electrical remodeling, and autonomic dysfunction are implicated in AF pathophysiology in diabetic hearts. Antidiabetic drugs have been demonstrated to possess therapeutic potential for AF. However, clinical investigations of AF in patients with DM have been scant and inconclusive. This article provides a comprehensive review of research findings on the association between DM and AF and critically analyzes the effect of different pharmacological classes of antidiabetic drugs on AF.

糖尿病（DM）是心房颤动（AF）的独立危险因素，它是最常见的持续性心律不齐，并与大量发病率和死亡率相关。晚期糖基化终产物及其受体激活，心脏能量代谢异常，结构和电重构以及自主神经功能紊乱与糖尿病心脏的AF病理生理有关。抗糖尿病药已被证明具有AF的治疗潜力。然而，对糖尿病患者房颤的临床研究很少，也尚无定论。本文对DM和AF之间的关联性研究结果进行了全面综述，并严格分析了抗糖尿病药物的不同药理类型对AF的影响。