Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. Advanced glycation end product and its receptor activation, cardiac energy dysmetabolism, structural and electrical remodeling, and autonomic dysfunction are implicated in AF pathophysiology in diabetic hearts. Antidiabetic drugs have been demonstrated to possess therapeutic potential for AF. However, clinical investigations of AF in patients with DM have been scant and inconclusive. This article provides a comprehensive review of research findings on the association between DM and AF and critically analyzes the effect of different pharmacological classes of antidiabetic drugs on AF.

糖尿病（DM）是房颤（AF）的独立危险因素，房颤是最常见的持续性心律失常，与大量的发病率和死亡率相关。晚期糖基化终产物及其受体激活、心脏能量代谢失调、结构和电重塑以及自主神经功能障碍与糖尿病心脏的 AF 病理生理学有关。抗糖尿病药物已被证明具有治疗 AF 的潜力。然而，对于 DM 患者的 AF 临床研究却很少且尚无定论。本文对 DM 和 AF 之间关联的研究结果进行了全面综述，并批判性地分析了不同药理学类别的抗糖尿病药物对 AF 的影响。