Abstract

Russian and international publications on the antiviral activity of medicinal mushrooms against influenza, which have been studied in cell culture and animal models, on the presence of sialidase (neuraminidase) inhibitors and RNA polymerase inhibitors of influenza virus are considered. The activity against influenza of both aqueous extracts of higher fungi and the polysaccharides, peptidoglycans, proteins, melanin, polyphenols, and terpenoids present in them is described. It is noted that further studies of the antiviral mechanisms of these components of medicinal mushrooms, both those grown in natural conditions and those cultivated with solid-phase or submerged methods in laboratory and factory conditions, are required in order to develop drugs based on them.

中文翻译：

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基于药用蘑菇的抗流感药物的发展前景（综述）

摘要

考虑了在细胞培养和动物模型中研究过的有关蘑菇对流感病毒的抗病毒活性的俄罗斯和国际出版物，其中考虑了唾液酸酶（神经氨酸酶）抑制剂和流感病毒的RNA聚合酶抑制剂的存在。描述了高级真菌的水提取物和其中存在的多糖，肽聚糖，蛋白质，黑色素，多酚和萜类化合物的抗流感活性。注意，为了开发基于它们的药物，需要进一步研究药用蘑菇的这些成分的抗病毒机理，无论是在自然条件下生长的那些，还是在实验室和工厂条件下以固相或淹没方法栽培的蘑菇。