Mesenchymal stromal cells (MSCs) can be derived from a wide range of fetal and adult sources including pluripotent stem cells (PSCs). The properties of PSC-derived MSCs need to be fully characterized, in order to evaluate the feasibility of their use in clinical applications. PSC-MSC proliferation and differentiation potential in comparison with bone marrow (BM)-MSCs is still under investigation. The objective of this study was to determine the proliferative and chondrogenic capabilities of both human induced pluripotent stem cell (hiPSC-) and embryonic stem cell (hESC-) derived MSCs, by comparing them with BM-MSCs.

中文翻译：

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来自多能细胞和骨髓细胞的间充质基质细胞的增殖和软骨形成潜力。

间充质基质细胞 (MSCs) 可以来自广泛的胎儿和成人来源，包括多能干细胞 (PSCs)。需要充分表征 PSC 衍生的 MSC 的特性，以评估其在临床应用中的可行性。PSC-MSC 与骨髓 (BM)-MSC 相比的增殖和分化潜力仍在研究中。本研究的目的是通过与 BM-MSC 进行比较，确定人类诱导多能干细胞 (hiPSC-) 和胚胎干细胞 (hESC-) 衍生的 MSCs 的增殖和软骨形成能力。