A new hypothesis based on structural and molecular heterogeneity of thermogenic adipocytes suggests that regulated thermogenesis in mammalian adipose tissues involves two structural-functional levels. The first level comprises typical brown fat and beige adipocytes of subcutaneous white fat depots. Being a part of the functional thermoregulatory system, this level of heat production is controlled by the appropriate hypothalamic centers. The second level is represented by visceral beige adipocytes with a relatively low total thermogenic capacity which provide a fine local adjustment of thermal optima for cell renewal processes. This level is regulated mainly by the local auto- and paracrine mechanisms.

中文翻译：

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脂肪组织中生热的两级组织：形态功能假说

基于产热脂肪细胞的结构和分子异质性的新假说表明，哺乳动物脂肪组织中调节生热作用涉及两个结构功能水平。第一级包括皮下白色脂肪贮库的典型棕色脂肪和米色脂肪细胞。作为功​​能性温度调节系统的一部分，该热量产生水平由适当的下丘脑中心控制。第二个水平是由内脏米色脂肪细胞代表的，这些内脏米色脂肪细胞具有相对较低的总产热能力，可为细胞更新过程提供最佳的最佳热局部调节。此水平主要受当地自分泌和旁分泌机制调节。