Acute rheumatic fever (ARF) is caused by an autoimmune response to throat infection with Streptococcus pyogenes in individuals who present some susceptibility genes. Rheumatic heart disease (RHD) is the major sequela and can cause heart failure and premature mortality. The disease is mediated by humoral and cellular immune responses. In this review, we present the major events that can trigger heart lesions.

中文翻译：

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风湿热：由于人类和病原体蛋白质之间的分子模拟引起的自身免疫性疾病模型

急性风湿热 (ARF) 是由存在一些易感基因的个体对化脓性链球菌的咽喉感染的自身免疫反应引起的。风湿性心脏病 (RHD) 是主要的后遗症，可导致心力衰竭和过早死亡。该疾病由体液和细胞免疫反应介导。在这篇综述中，我们介绍了可引发心脏病变的主要事件。