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MODELING AND SIMULATION OF SKELETAL MUSCLE BASED ON METABOLISM PHYSIOLOGY
Journal of Mechanics in Medicine and Biology ( IF 0.8 ) Pub Date : 2020-09-22
MONAN WANG, JIALIN HAN, QIYOU YANG

Skeletal muscle energy metabolism plays a very important role in controlling movement of the whole body and has important theoretical guidance for making exercise training plans and losing weight. In this paper, we developed a mathematical model of skeletal muscle excitation–contraction pathway based on the energy metabolism that links excitation to contraction to explore the effects of different metabolic energy systems on calcium ion changes and the force during skeletal muscle contraction. In this paper, a membrane potential model, a calcium cycle model, a cross-bridge dynamics model and an energy metabolism model were established. Finally, the physiological phenomenon of calcium ion transport and calcium ion concentration change of the sarcoplasm was simulated. The results show that the phosphagen system has the fastest metabolic rate and the phosphagen system has the largest impact on the explosive power of skeletal muscle exercise. The specific characteristics of the three metabolic energy systems supporting skeletal muscle movement in vivo were also analyzed in detail.



中文翻译:

基于代谢生理学的骨骼肌建模与仿真

骨骼肌能量代谢在控制全身运动中起着非常重要的作用,对制定运动训练计划和减轻体重具有重要的理论指导。在本文中,我们基于能量代谢将兴奋与收缩联系起来,建立了骨骼肌兴奋-收缩途径的数学模型,以探索不同代谢能量系统对骨骼肌收缩过程中钙离子变化和作用力的影响。本文建立了膜电势模型,钙循环模型,跨桥动力学模型和能量代谢模型。最后,模拟了肌浆中钙离子转运和钙离子浓度变化的生理现象。结果表明,磷素系统具有最快的代谢速率,而磷素系统对骨骼肌运动的爆发力影响最大。支持骨骼肌运动的三种代谢能系统的特定特征体内也进行了详细分析。

更新日期:2020-09-22
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