Thionated organic compounds as emerging heavy-atom-free photodynamic therapy agents,Chemical Science

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Thionated organic compounds as emerging heavy-atom-free photodynamic therapy agents
Chemical Science ( IF 7.6 ) Pub Date : 2020-09-22 , DOI: 10.1039/d0sc04747c
Luis A Ortiz-Rodríguez ₁ , Carlos E Crespo-Hernández ₁

Affiliation

This minireview focuses on recent progress in developing heavy-atom-free photosensitizers based on the thionation of nucleic acid derivatives and other biocompatible organic compounds for prospective applications in photodynamic therapy. Particular attention is given to the use of thionated nucleobase derivatives as “one-two punch” photodynamic agents. These versatile photosensitizers can act as “Trojan horses” upon metabolization into DNA and exposure to activating light. Their incorporation into cellular DNA increases their selectivity and photodynamic efficacy against highly proliferating skin cancer tumor cells, while simultaneously enabling the use of low irradiation doses both in the presence and in the absence of molecular oxygen. Also reviewed are their primary photochemical reactions, modes of action, and photosensitization mechanisms. New developments of emerging thionated organic photosensitizers absorbing visible and near-infrared radiation are highlighted. Future research directions, as well as, other prospective applications of heavy-atom-free, thionated photosensitizers are discussed.

中文翻译：

硫代有机化合物作为新兴的无重原子光动力治疗剂

这篇小综述重点介绍了基于核酸衍生物和其他生物相容性有机化合物硫化的无重原子光敏剂的最新进展，以用于光动力疗法的前瞻性应用。特别关注硫代核碱基衍生物作为“一二冲”光动力剂的使用。这些多功能光敏剂在代谢为 DNA 并暴露在活化光下时可以充当“特洛伊木马”。它们与细胞 DNA 的结合增加了它们对高度增殖的皮肤癌肿瘤细胞的选择性和光动力功效，同时使得在存在和不存在分子氧的情况下都能够使用低辐射剂量。还回顾了它们的主要光化学反应、作用模式和光敏机制。重点介绍了吸收可见光和近红外辐射的新兴硫化有机光敏剂的新发展。讨论了未来的研究方向以及无重原子硫化光敏剂的其他前瞻性应用。

更新日期：2020-09-22

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