Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes
Chemical Communications ( IF 4.3 ) Pub Date : 2020-09-22 , DOI: 10.1039/d0cc05887d
Yunhe Lv _{1,

2,

3,

4} , Weiya Pu _{1,

2,

3,

4} , Xiaoxing Wang _{1,

2,

3,

4}

Affiliation

The copper-catalyzed highly regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes with α-chloroacetamides and dialkyl 2-fluoromalonate or 2-fluoro-N,N-dialkyl-3-oxobutanamide without an external ligand has been realized. With this novel methodology, (E)-β-monofluoroalkyl-β,γ-unsaturated amides containing quaternary C–F centers can be easily constructed in good to excellent yields.

中文翻译：

末端炔烃的无配体铜催化的区域和立体选择性1,1-烷基单氟烷基化

已经实现了具有α-氯乙酰胺和2-氟丙二酸二烷基酯或2-氟-N，N-二烷基-3-氧代丁酰胺的末端炔烃的铜催化的高度区域和立体选择性的1,1-烷基单氟烷基化，而没有外部配体。用这种新颖的方法，可以容易地以良好或极好的收率构建含（E）-β-单氟烷基-β，γ-不饱和酰胺的季C-F中心。

更新日期：2020-09-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11