Basic and clinical research have demonstrated that osteoprotegerin (OPG) plays an important role in the development and progression of cardiovascular diseases. The aim of this study was to evaluate the association of four polymorphic sites (rs2073618, rs3134069, rs3134070, and rs3102735) of OPG gene with premature coronary artery disease (pCAD), and with cardiometabolic parameters. The polymorphisms were genotyped using 5′ exonuclease TaqMan genotyping assays with real-time PCR in 1098 individuals with pCAD and 1041 healthy controls. rs2073618 polymorphism was associated with a high risk of developing pCAD according to different inheritance models: additive (p = 0.001; odds ratio [OR] = 1.283), dominant (p = 0.006; OR = 1.383), recessive (p = 0.011; OR = 1.423), and codominant 2 (p = 0.001; OR = 1.646). The four polymorphisms were associated with different cardiovascular risk factors in individuals with pCAD and controls. Our results suggest that OPG rs2073618 polymorphism is associated with an increased risk of pCAD. In addition, two haplotypes were associated with pCAD, one increasing the risk (CACT) and another one as protective (GACC).

中文翻译：

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OPG 基因中的遗传变异和单倍型与墨西哥人群的早发冠状动脉疾病和传统心血管危险因素相关：GEA 研究。

基础和临床研究表明，骨保护素（OPG）在心血管疾病的发生发展中起着重要作用。本研究的目的是评估OPG基因的四个多态位点（rs2073618、rs3134069、rs3134070 和 rs3102735）与早发性冠状动脉疾病 (pCAD) 以及心脏代谢参数的关联。使用 5' 核酸外切酶 TaqMan 基因分型分析和实时 PCR 在 1098 名 pCAD 个体和 1041 名健康对照者中对多态性进行基因分型。根据不同的遗传模型，rs2073618 多态性与患 pCAD 的高风险相关：加性（p  = 0.001；优势比 [OR] = 1.283）、显性（p  = 0.006；OR = 1.383）、隐性（p = 0.011; OR = 1.423）和共显性 2（p  = 0.001；OR = 1.646）。这四种多态性与 pCAD 和对照个体的不同心血管危险因素相关。我们的结果表明OPG rs2073618 多态性与 pCAD 风险增加有关。此外，两种单倍型与 pCAD 相关，一种增加风险 ( CACT )，另一种具有保护性 ( GACC )。