Viruses remain a major challenge in the fierce fight against diseases. There have been many pandemics caused by various viruses throughout the world over the years. Recently, the global outbreak of COVID-19 has had a catastrophic impact on human health and the world economy. Antiviral drug treatment has become another essential means to overcome pandemics in addition to vaccine development. How to quickly find effective drugs that can control the development of a pandemic is a hot issue that still needs to be resolved in medical research today. To accelerate the development of drugs, it is necessary to target the key target proteins in the development of the pandemic, screen active molecules, and develop reliable methods for the identification and characterization of target proteins based on the active ingredients of drugs. This article discusses key target proteins and their biological mechanisms in the progression of COVID-19 and other major epidemics. We propose a model based on these foundations, which includes identifying potential core targets, screening potential active molecules of core targets, and verifying active molecules. This article summarizes the related innovative technologies and methods. We hope to provide a reference for the screening of drugs related to pandemics and the development of new drugs.

中文翻译：

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大流行中潜在蛋白质靶点发现和活性药物分子筛选的技术和策略。

病毒仍然是与疾病的激烈斗争中的主要挑战。多年来，世界各地发生了许多由各种病毒引起的流行病。近期，新冠肺炎（COVID-19）在全球爆发，对人类健康和世界经济造成了灾难性影响。抗病毒药物治疗已成为除疫苗研发之外战胜流行病的又一重要手段。如何快速找到能够控制疫情发展的有效药物，是当今医学研究仍需解决的热点问题。加快药物研发，需要针对疫情发展中的关键靶蛋白，筛选活性分子，并根据药物活性成分开发可靠的靶蛋白鉴定和表征方法。本文讨论了 COVID-19 和其他主要流行病进展中的关键靶蛋白及其生物学机制。我们基于这些基础提出了一个模型，包括识别潜在的核心靶点、筛选核心靶点的潜在活性分子以及验证活性分子。本文对相关创新技术和方法进行了总结。希望为流行病相关药物的筛选和新药的研发提供参考。