Neurological diseases are a major threat to global public health and prosperity. The number of patients with neurological diseases is increasing due to the population aging and increasing life expectancy. Autophagy is one of the crucial mechanisms to maintain nerve cellular homeostasis. Numerous studies have demonstrated that autophagy plays a dual role in neurological diseases. Long noncoding RNAs (lncRNAs) are a vital class of noncoding RNAs with a length of more than 200 nucleotides and cannot encode proteins themselves but are expressed in most neurological diseases. An early phase, emerging knowledge has revealed that long noncoding RNAs (lncRNAs) are crucial in autophagy regulation. Furthermore, autophagy-associated lncRNAs can promote the development of neurological diseases or slow their progression. In this review, we introduce a general overview of lncRNA functional mechanisms and summarizes the recent progress of lncRNAs on autophagy regulation in neurological diseases to reveal possible novel therapeutic targets or useful biomarkers.

中文翻译：

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自噬相关的 lncRNA：神经疾病诊断和治疗的有希望的靶点

神经系统疾病是全球公共卫生和繁荣的主要威胁。由于人口老龄化和预期寿命的增加，神经系统疾病患者的数量正在增加。自噬是维持神经细胞稳态的关键机制之一。大量研究表明，自噬在神经系统疾病中起着双重作用。长链非编码 RNA (lncRNA) 是一类重要的非编码 RNA，长度超过 200 个核苷酸，本身不能编码蛋白质，但在大多数神经系统疾病中表达。早期的新兴知识表明，长链非编码 RNA (lncRNA) 在自噬调节中至关重要。此外，自噬相关的 lncRNA 可以促进神经系统疾病的发展或减缓其进展。在这次审查中，