We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and raster-scanned over a sample at the distal tip of the fiber by use of a fast spatial light modulator. An ultra-sensitive fiber-optic ultrasound sensor for photoacoustic detection placed next to the fiber is combined with a photodetector to obtain both fluorescence and photoacoustic images with a distal imaging tip no larger than 250 µm. The high signal-to-noise ratio provided by wavefront shaping based focusing and the ultra-sensitive ultrasound sensor enables imaging with a single laser shot per pixel, demonstrating fast two-dimensional hybrid in vitro imaging of red blood cells and fluorescent beads.

中文翻译：

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通过波前成形的多模光纤进行单次混合光声-荧光显微内窥镜检查

我们提出了一种基于微模式光纤的微创内窥镜，其结合了光声和荧光传感。通过在先前的校准步骤期间测量透射矩阵，可以使用快速空间光调制器在光纤远端处的样品上生成聚焦点并进行光栅扫描。与光纤相邻放置的用于光声检测的超灵敏光纤超声传感器与光电检测器组合，以获取远端成像尖端不大于250 µm的荧光图像和光声图像。通过基于波前整形的聚焦和超灵敏的超声传感器提供的高信噪比，可以对每个像素进行一次激光照射成像，从而证明了体外的快速二维混合 血细胞和荧光珠成像。