Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads,ACS Medicinal Chemistry Letters

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Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-09-21 , DOI: 10.1021/acsmedchemlett.0c00314
Fan Pu ₁ , Nathaniel L Elsen ₁ , Jon D Williams ₁

Affiliation

Mass spectrometry (MS) detection can offer unmatched selectivity and sensitivity. The use of MS without chromatography greatly increases the throughput, making it suitable for high throughput screening. However, the trade-offs of direct MS detection need to be carefully evaluated along with the development of novel strategies to ensure successful implementation. In this review, we will discuss the pros and cons of chromatography-free MS and discuss some of the currently used and future technologies being investigated to enable high-throughput MS.

中文翻译：

用于生成命中和先导化合物的新兴免色谱高通量质谱技术

质谱 (MS) 检测可提供无与伦比的选择性和灵敏度。使用无需色谱法的 MS 大大提高了通量，使其适合高通量筛选。然而，需要仔细评估直接 MS 检测的利弊以及新策略的开发，以确保成功实施。在这篇综述中，我们将讨论免色谱 MS 的优缺点，并讨论一些当前使用的和未来正在研究的技术，以实现高通量 MS。

更新日期：2020-11-12

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