Adipose tissue (AT) forms depots at different anatomical locations throughout the body, being in subcutaneous and visceral regions, as well as the bone marrow. These ATs differ in the adipocyte functional profile, their insulin sensitivity, adipokines’ production, lipolysis, and response to pathologic conditions. Despite the recent advances in lineage tracing, which have demonstrated that individual adipose depots are composed of adipocytes derived from distinct progenitor populations, the cellular and molecular dissection of the adipose clonogenic stem cell niche is still a great challenge. Additional complexity in AT regulation is associated with tumor-induced changes that affect adipocyte phenotype. As an integrative unit of cell differentiation, AT microenvironment regulates various phenotype outcomes of differentiating adipogenic lineages, which consequently may contribute to the neoplastic phenotype manifestations. Particularly interesting is the capacity of AT to impose and support the aberrant potency of stem cells that accompanies tumor development. In this review, we summarize the current findings on the communication between adipocytes and their progenitors with tumor cells, pointing out to the co-existence of healthy and neoplastic stem cell niches developed during tumor evolution. We also discuss tumor-induced adaptations in mature adipocytes and the involvement of alternative differentiation programs.

脂肪组织（AT）在整个身体的不同解剖位置处形成储库，位于皮下和内脏区域以及骨髓中。这些AT的脂肪细胞功能特征，胰岛素敏感性，脂肪因子的产生，脂解作用以及对病理状况的反应不同。尽管谱系追踪方面的最新进展表明单个脂肪库由来自不同祖细胞的脂肪细胞组成，但是脂肪克隆形成干细胞的利基细胞和分子解剖仍然是一个巨大的挑战。AT调节的其他复杂性与肿瘤诱导的影响脂肪细胞表型的变化有关。作为细胞分化的整合单元，AT微环境调节分化成脂谱系的各种表型结果，因此可能有助于肿瘤表型的表现。特别令人感兴趣的是AT赋予并支持伴随肿瘤发展的干细胞异常效力的能力。在这篇综述中，我们总结了关于脂肪细胞及其祖细胞与肿瘤细胞之间的通讯的最新发现，指出了在肿瘤进化过程中健康和肿瘤干细胞生态位的共存。我们还讨论了成熟脂肪细胞中肿瘤诱导的适应性以及其他分化程序的参与。我们总结了有关脂肪细胞及其祖细胞与肿瘤细胞之间的通讯的最新发现，指出了在肿瘤进化过程中健康和肿瘤干细胞生态位的共存。我们还讨论了成熟脂肪细胞中肿瘤诱导的适应性以及其他分化程序的参与。我们总结了有关脂肪细胞及其祖细胞与肿瘤细胞之间的通讯的最新发现，指出了在肿瘤进化过程中健康和肿瘤干细胞生态位的共存。我们还讨论了成熟脂肪细胞中肿瘤诱导的适应性以及其他分化程序的参与。