We show that H-bonded host–guest systems associate in ionic liquids (ILs), pure salts with melting point below room temperature, in which dipole–dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (K_a) obtained from titrations of four H-bonded host–guest systems in two organic solvents and two ionic liquids yield smaller yet comparable K_a values in ionic liquids than in organic solvents. We also detect the association event using force spectroscopy, which confirms that the binding is not solely due to (de)solvation processes. Our results indicate that classic H-bonded host–guest supramolecular chemistry takes place in ILs. This implies that strong H-bonds are only moderately affected by surroundings composed entirely of charges, which can be interpreted as an indication that the balance of Coulombic to covalent forces in strong H-bonds is not tipped towards the former.

我们表明氢键主客体系统在离子液体（ILs）中结合，离子液体是熔点低于室温的纯盐，与偶极电荷相互作用相比，其中偶极-偶极静电相互作用应该可以忽略不计。通过在两种有机溶剂和两种离子液体中滴定四种 H 键主客体系统获得的结合常数 ( K _a ) 产生较小但相当的K _a离子液体中的值高于有机溶剂中的值。我们还使用力谱检测了关联事件，这证实了结合不仅仅是由于（去）溶剂化过程。我们的结果表明经典的 H 键主客体超分子化学发生在 ILs 中。这意味着强氢键仅受完全由电荷组成的环境的适度影响，这可以解释为表明强氢键中库仑力与共价力的平衡不倾向于前者。