Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker whose clinical value has been tested in various groups of patients. The aim of the present study was to determine the suPAR level in a previously uninvestigated population of 182, generally healthy, community-dwelling seniors aged 74–89 years. In addition to suPAR level, selected laboratory parameters of heart and kidney function, lipid and C-reactive protein levels were determined. A group of 45 younger individuals aged 24–66 years was used for comparison. The seniors had higher suPAR levels than younger controls: 3.79 ng/mL (95% CI 3.64–3.96 ng/mL) vs. 3.16 ng/mL (95% CI 2.86–3.45 ng/mL). These levels increased further with advancing age, and were similar in women and men. A multiple regression model confirmed that biomarker level was related to cardiac function, renal function and inflammation, and this remained after adjusting for age. These correlation patterns were similar in older women and men.

可溶性尿激酶纤溶酶原激活物受体 (suPAR) 是一种生物标志物，其临床价值已在各种患者群体中进行了测试。本研究的目的是确定先前未经调查的 182 名年龄在 74-89 岁之间的总体健康社区老年人的 suPAR 水平。除了 suPAR 水平外，还确定了心脏和肾脏功能、脂质和 C 反应蛋白水平的选定实验室参数。一组 45 名年龄在 24-66 岁之间的年轻人被用于比较。老年人的 suPAR 水平高于年轻对照组：3.79 ng/mL (95% CI 3.64–3.96 ng/mL) 与 3.16 ng/mL (95% CI 2.86–3.45 ng/mL)。这些水平随着年龄的增长而进一步增加，并且在女性和男性中相似。多元回归模型证实生物标志物水平与心功能有关，肾功能和炎症，这在调整年龄后仍然存在。这些相关模式在老年女性和男性中是相似的。