Diets low in seafood omega-3 polyunsaturated fatty acids (PUFAs) are very prevalent. Such diets have recently been ranked as the sixth most important dietary risk factor—1.5 million deaths and 33 million disability-adjusted life-years worldwide are attributable to this deficiency. Wild oily fish stocks are insufficient to feed the world’s population, and levels of eicosapentaenoic acid and docosahexaenoic acid (DHA) in farmed fish have more than halved in the last 20 years. Here we report on a double-blinded, controlled trial, where 161 healthy normotensive adults were randomly allocated to eat at least three portions/week of omega-3-PUFA enriched (or control) chicken-meat, and to eat at least three omega-3-PUFA enriched (or control) eggs/week, for 6 months. We show that regular consumption of omega-3-PUFA enriched chicken-meat and eggs significantly increased the primary outcome, the red cell omega-3 index (mean difference [98.75% confidence interval] from the group that ate both control foods, 1.7% [0.7, 2.6]). Numbers of subjects with a very high-risk omega-3 index (index < 4%) were more than halved amongst the group that ate both enriched foods. Furthermore, eating the enriched foods resulted in clinically relevant reductions in diastolic blood pressure (− 3.1 mmHg [− 5.8, − 0.3]). We conclude that chicken-meat and eggs, naturally enriched with algae-sourced omega-3-PUFAs, may serve as alternative dietary sources of these essential micronutrients. Unlike many lifestyle interventions, long-term population health benefits do not depend on willingness of individuals to make long-lasting difficult dietary changes, but on the availability of a range of commonly eaten, relatively inexpensive, omega-3-PUFA enriched foods.

海鲜 omega-3 多不饱和脂肪酸 (PUFA) 含量低的饮食非常普遍。此类饮食最近被列为第六大最重要的饮食风险因素——全球 150 万人死亡和 3300 万残疾调整生命年可归因于这种缺乏。野生油性鱼类资源不足以养活世界人口，养殖鱼类中的二十碳五烯酸和二十二碳六烯酸 (DHA) 水平在过去 20 年中减少了一半以上。在这里，我们报告了一项双盲对照试验，其中 161 名健康正常血压的成年人被随机分配每周至少吃三份富含 omega-3-PUFA（或对照）的鸡肉，并至少吃三份 omega-3-PUFA -3-PUFA 富集（或对照）鸡蛋/周，持续 6 个月。我们表明，经常食用富含 omega-3-PUFA 的鸡肉和鸡蛋可显着增加主要结果，即红细胞 omega-3 指数（与同时食用两种对照食物的组的平均差异 [98.75% 置信区间]，1.7%） [0.7, 2.6])。在同时食用两种富含食物的组中，具有极高风险 omega-3 指数（指数 < 4%）的受试者数量减少了一半以上。此外，食用富含营养的食物会导致舒张压的临床相关降低（− 3.1 mmHg [− 5.8, − 0.3]）。我们得出的结论是，天然富含藻类来源的 omega-3-PUFA 的鸡肉和鸡蛋可以作为这些必需微量营养素的替代膳食来源。与许多生活方式干预不同，